Mucoadhesion : a New Polymeric Controlled Drug Delivery
نویسندگان
چکیده
Since last three decades delivery of the desired drug as muocoadhesive drug delivery systems has been subject of interest. Mucoadhesion involving a polymeric drug delivery system is a complex phenomenon that includes theory of diffusion, wetting, adsorption, fracture and interpenetration of polymer chains amongst various other processes. Various polymer-based properties such as the degree of cross-linking, chain length, hydration, pH and various functional groupings can influenced the mucoadhesion bonding with polymer. With the right dosage form design, local environment of the mucosa can be controlled and manipulated in order to optimize the rate of drug dissolution and permeation. In research various set up of in vitro and in vivo mucoadhesion testing carried out to select correct adhesive drug delivery technique. Mucoadhesive drug delivery system has wide application such as buccal, ophthalmic, nasal and vaginal drug delivery.
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